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Entry
N00510                      Network                                

Name
HTLV-1 Tax to CREB-mediated transcription
Definition
htlvTAX -> CREB3 => CCND1
  Expanded
K21857 -> 10488 => 595
Class
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Pathogen
Pathway
hsa05166  Human T-cell leukemia virus 1 infection
Disease
H00009  Adult T-cell leukemia
Gene
10488  CREB3; cAMP responsive element binding protein 3
595  CCND1; cyclin D1
Perturbant
K21857  tax; protein Tax-1
Reference
  Authors
Azran I, Schavinsky-Khrapunsky Y, Aboud M
  Title
Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
  Journal
Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20
Reference
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
  Authors
Kim YM, Geiger TR, Egan DI, Sharma N, Nyborg JK
  Title
The HTLV-1 tax protein cooperates with phosphorylated CREB, TORC2 and p300 to activate CRE-dependent cyclin D1 transcription.
  Journal
Oncogene 29:2142-52 (2010)
DOI:10.1038/onc.2009.498
Reference
  Authors
Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY
  Title
TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats.
  Journal
J Virol 80:7052-9 (2006)
DOI:10.1128/JVI.00103-06
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