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Entry
N00518                      Network                                

Name
HCV Core to ERK signaling pathway
Definition
hcvCore -| YWHA -| RAF -> MEK -> ERK
  Expanded
K22271 -| (10971,7529,7531,7532,7533,7534) -| (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06110 MAPK signaling (virus)
nt06163 Hepatitis C virus (HCV)
Type
Virus
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
10971  YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
7529  YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
7531  YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
7532  YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
7533  YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
7534  YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Perturbant
K22271  Core; HCV core protein
Reference
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
  Authors
Aoki H, Hayashi J, Moriyama M, Arakawa Y, Hino O
  Title
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.
  Journal
J Virol 74:1736-41 (2000)
DOI:10.1128/JVI.74.4.1736-1741.2000
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