KEGG   NETWORK: N00519Help
Entry
N00519                      Network                                

Name
HCV Core to ERK signaling pathway
Definition
hcvCore -> MEK -> ERK
  Expanded
K22271 -> (5604,5605) -> (5594,5595)
Class
nt06263 Hepatocellular carcinoma
nt06110 MAPK signaling (viruses)
nt06163 Hepatitis C virus (HCV)
Type
Pathogen
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Perturbant
K22271  Core; HCV core protein
Reference
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
  Authors
Giambartolomei S, Covone F, Levrero M, Balsano C
  Title
Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the Hepatitis C Virus (HCV) core protein.
  Journal
Oncogene 20:2606-10 (2001)
DOI:10.1038/sj.onc.1204372
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