KEGG   NETWORK: N00520Help
Entry
N00520                      Network                                

Name
HCV NS5A to p21-cell cycle G1/S
Definition
hcvNS5A -| TP53 => CDKN1A
  Expanded
K22275 -| 7157 => 1026
Class
nt06263 Hepatocellular carcinoma
nt06130 Cell cycle (viruses)
nt06163 Hepatitis C virus (HCV)
Type
Pathogen
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
7157  TP53; tumor protein p53
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
Perturbant
K22275  NS5A; HCV non-structural protein 5A
Reference
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
  Authors
Tran G.
  Title
The role of hepatitis C virus in the pathogenesis of hepatocellular carcinoma
  Journal
Bioscience Horizons 1(2):167-175 (2008)
Reference
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
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