KEGG   NETWORK: N00521Help
Entry
N00521                      Network                                

Name
HCV Core to p21-cell cycle G1/S
Definition
hcvCore -| TP53 => CDKN1A -| CDK4/6 -> RB1 // E2F
  Expanded
K22271 -| 7157 => 1026 -| (1019,1021) -> 5925 // (1869,1870,1871)
Class
nt06130 Cell cycle (virus)
nt06163 Hepatitis C virus (HCV)
Type
Virus
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
7157  TP53; tumor protein p53
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
1019  CDK4; cyclin dependent kinase 4
1021  CDK6; cyclin dependent kinase 6
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Perturbant
K22271  Core; HCV core protein
Reference
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:9110985
  Authors
Ray RB, Steele R, Meyer K, Ray R
  Title
Transcriptional repression of p53 promoter by hepatitis C virus core protein.
  Journal
J Biol Chem 272:10983-6 (1997)
DOI:10.1074/jbc.272.17.10983
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