KEGG   NETWORK: N00521
Entry
N00521                      Network                                

Name
HCV Core to p21-cell cycle G1/S
Definition
Core -| TP53
  Expanded
K22271 -| 7157
Class
nt06263 Hepatocellular carcinoma
nt06130 Cell cycle (viruses)
nt06163 Hepatitis C virus (HCV)
Type
Pathogen
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
7157  TP53; tumor protein p53
Perturbant
K22271 (Core)  Core; HCV core protein
Reference
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:9110985
  Authors
Ray RB, Steele R, Meyer K, Ray R
  Title
Transcriptional repression of p53 promoter by hepatitis C virus core protein.
  Journal
J Biol Chem 272:10983-6 (1997)
DOI:10.1074/jbc.272.17.10983
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