KEGG   NETWORK: N00526
Entry
N00526                      Network                                

Name
HCV NS3 to crosstalk between extrinsic and intrinsic apoptotic pathways
Definition
NS3 -> CASP8 -> BID -> (BAX,BAK1) -> CYCS -- APAF1 -> CASP9 -> CASP3
  Expanded
K22273 -> 841 -> 637 -> (581,578) -> 54205 -- 317 -> 842 -> 836
Class
nt06263 Hepatocellular carcinoma
nt06131 Apoptosis (viruses and bacteria)
nt06163 Hepatitis C virus (HCV)
Type
Pathogen
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
841  CASP8; caspase 8
637  BID; BH3 interacting domain death agonist
581  BAX; BCL2 associated X, apoptosis regulator
578  BAK1; BCL2 antagonist/killer 1
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
Perturbant
K22273 (NS3)  NS3; HCV serine protease NS3
Reference
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
  Journal
World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865
Reference
  Authors
Prikhod'ko EA, Prikhod'ko GG, Siegel RM, Thompson P, Major ME, Cohen JI
  Title
The NS3 protein of hepatitis C virus induces caspase-8-mediated apoptosis independent of its protease or helicase activities.
  Journal
Virology 329:53-67 (2004)
DOI:10.1016/j.virol.2004.08.012
Reference
  Authors
Lim EJ, Chin R, Angus PW, Torresi J
  Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
  Journal
World J Gastroenterol 18:2172-9 (2012)
DOI:10.3748/wjg.v18.i18.2172
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