KEGG   NETWORK: N00528Help
Entry
N00528                      Network                                

Name
HCV core to extrinsic apoptotic pathway
Definition
hcvCore -> CFLAR -| CASP8 -> CASP3
  Expanded
K22271 -> 8837 -| 841 -> 836
Class
nt06263 Hepatocellular carcinoma
nt06131 Apoptosis (viruses and bacteria)
nt06163 Hepatitis C virus (HCV)
Type
Pathogen
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
8837  CFLAR; CASP8 and FADD like apoptosis regulator
841  CASP8; caspase 8
836  CASP3; caspase 3
Perturbant
K22271  Core; HCV core protein
Reference
  Authors
Kim H, Ray R
  Title
Evasion of TNF-alpha-mediated apoptosis by hepatitis C virus.
  Journal
Methods Mol Biol 1155:125-32 (2014)
DOI:10.1007/978-1-4939-0669-7_11
Reference
  Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
  Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
  Journal
J Virol 80:4372-9 (2006)
DOI:10.1128/JVI.80.9.4372-4379.2006
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