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Entry
N00530                      Network                                

Name
HCV core to RXRA/LXRA-mediated transcription
Definition
(hcvCore+PSME3) -> (RXRA+NR1H3) => (CCND1,CDK4,MYC)
  Expanded
(K22271+10197) -> (6256+10062) => (595,1019,4609)
Class
nt06163 Hepatitis C virus (HCV)
Type
Virus
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
10197  PSME3; proteasome activator subunit 3
6256  RXRA; retinoid X receptor alpha
10062  NR1H3; nuclear receptor subfamily 1 group H member 3
595  CCND1; cyclin D1
1019  CDK4; cyclin dependent kinase 4
4609  MYC; MYC proto-oncogene, bHLH transcription factor
Perturbant
K22271  Core; HCV core protein
Reference
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
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