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Entry
N00531                      Network                                

Name
HBV HBx to TGF-beta signaling pathway
Definition
hbvX -> TGFB -> (TGFBR2+TGFBR1) -> (SMAD2,SMAD3) -- SMAD4
  Expanded
K21854 -> (7040,7042,7043) -> (7048+7046) -> (4087,4088) -- 4089
Class
nt06263 Hepatocellular carcinoma
nt06118 TGFB signaling (viruses)
nt06162 Hepatitis B virus (HBV)
Type
Pathogen
Pathway
hsa05161  Hepatitis B
Disease
H00048  Hepatocellular carcinoma
Gene
7040  TGFB1; transforming growth factor beta 1
7042  TGFB2; transforming growth factor beta 2
7043  TGFB3; transforming growth factor beta 3
7048  TGFBR2; transforming growth factor beta receptor 2
7046  TGFBR1; transforming growth factor beta receptor 1
4087  SMAD2; SMAD family member 2
4088  SMAD3; SMAD family member 3
4089  SMAD4; SMAD family member 4
Perturbant
K21854  X; HBV protein X
Reference
PMID:8567959
  Authors
Yoo YD, Ueda H, Park K, Flanders KC, Lee YI, Jay G, Kim SJ
  Title
Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis.
  Journal
J Clin Invest 97:388-95 (1996)
DOI:10.1172/JCI118427
Reference
  Authors
Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z
  Title
Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.
  Journal
Cancer Lett 286:69-79 (2009)
DOI:10.1016/j.canlet.2008.12.010
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