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Entry
N00536                      Network                                

Name
MDM2-p21-Cell cycle G1/S
Definition
CDKN2A -| MDM2 -| TP53 => CDKN1A -| (CCNE+CDK2) -> RB1 // E2F
  Expanded
1029 -| 4193 -| 7157 => 1026 -| ((898,9134)+1017) -> 5925 // (1869,1870,1871)
Class
nt06130 Cell cycle (virus)
nt06162 Hepatitis B virus (HBV)
Type
Reference
Pathway
hsa04110  Cell cycle
Gene
1029  CDKN2A; cyclin dependent kinase inhibitor 2A
4193  MDM2; MDM2 proto-oncogene
7157  TP53; tumor protein p53
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
898  CCNE1; cyclin E1
9134  CCNE2; cyclin E2
1017  CDK2; cyclin dependent kinase 2
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Reference
  Authors
Sheppard KE, McArthur GA
  Title
The cell-cycle regulator CDK4: an emerging therapeutic target in melanoma.
  Journal
Clin Cancer Res 19:5320-8 (2013)
DOI:10.1158/1078-0432.CCR-13-0259
Reference
  Authors
Subramanian M, Jones MF, Lal A
  Title
Long Non-Coding RNAs Embedded in the Rb and p53 Pathways.
  Journal
Cancers (Basel) 5:1655-75 (2013)
DOI:10.3390/cancers5041655
Reference
  Authors
Otto T, Sicinski P
  Title
Cell cycle proteins as promising targets in cancer therapy.
  Journal
Nat Rev Cancer 17:93-115 (2017)
DOI:10.1038/nrc.2016.138
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