KEGG   NETWORK: N00537Help
Entry
N00537                      Network                                

Name
HBV HBx to cell cycle G1/S
Definition
hbvX -> (CCNE+CDK2) -> RB1 // E2F
  Expanded
K21854 -> ((898,9134)+1017) -> 5925 // (1869,1870,1871)
Class
nt06263 Hepatocellular carcinoma
nt06130 Cell cycle (viruses)
nt06162 Hepatitis B virus (HBV)
Type
Pathogen
Pathway
hsa05161  Hepatitis B
Disease
H00048  Hepatocellular carcinoma
Gene
898  CCNE1; cyclin E1
9134  CCNE2; cyclin E2
1017  CDK2; cyclin dependent kinase 2
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Perturbant
K21854  X; HBV protein X
Reference
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
  Authors
Mukherji A, Janbandhu VC, Kumar V
  Title
HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1.
  Journal
Biochem J 401:247-56 (2007)
DOI:10.1042/BJ20061091
LinkDB All DBs

DBGET integrated database retrieval system