KEGG   NETWORK: N00542Help
Entry
N00542                      Network                                

Name
EGF-EGFR-RAS-JNK signaling pathway
Definition
EGF -> EGFR -> GRB2 -> SOS -> RAS -> MEKK1 -> MKK4 -> JNK
  Expanded
1950 -> 1956 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> 4214 -> 6416 -> (5599,5601,5602)
Class
nt06110 MAPK signaling (virus)
nt06162 Hepatitis B virus (HBV)
Type
Reference
Pathway
hsa04010  MAPK signaling pathway
Gene
1950  EGF; epidermal growth factor
1956  EGFR; epidermal growth factor receptor
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
4214  MAP3K1; mitogen-activated protein kinase kinase kinase 1
6416  MAP2K4; mitogen-activated protein kinase kinase 4
5599  MAPK8; mitogen-activated protein kinase 8
5601  MAPK9; mitogen-activated protein kinase 9
5602  MAPK10; mitogen-activated protein kinase 10
Reference
  Authors
Haddad RI, Shin DM
  Title
Recent advances in head and neck cancer.
  Journal
N Engl J Med 359:1143-54 (2008)
DOI:10.1056/NEJMra0707975
Reference
  Authors
Reuter CW, Morgan MA, Bergmann L
  Title
Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?
  Journal
Blood 96:1655-69 (2000)
Reference
PMID:9681884
  Authors
Verheij M, Ruiter GA, Zerp SF, van Blitterswijk WJ, Fuks Z, Haimovitz-Friedman A, Bartelink H
  Title
The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis.
  Journal
Radiother Oncol 47:225-32 (1998)
DOI:10.1016/S0167-8140(98)00007-3
Reference
  Authors
Zhao HF, Wang J, Tony To SS
  Title
The phosphatidylinositol 3-kinase/Akt and c-Jun N-terminal kinase signaling in cancer: Alliance or contradiction? (Review).
  Journal
Int J Oncol 47:429-36 (2015)
DOI:10.3892/ijo.2015.3052
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