KEGG   NETWORK: N00549Help
Entry
N00549                      Network                                

Name
HBV HBeAg to TLR2/4-NFKB signaling pathway
Definition
hbvC -| MYD88 -> (IRAK4+IRAK1) -> (TRAF6+TAK1+TAB2) -> IKK -> NFKBIA -> NFKB
  Expanded
K23129 -| 4615 -> (51135+3654) -> (7189+6885+23118) -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06263 Hepatocellular carcinoma
nt06121 TLR signaling (viruses and bacteria)
nt06162 Hepatitis B virus (HBV)
Type
Pathogen
Pathway
hsa05161  Hepatitis B
Disease
H00048  Hepatocellular carcinoma
Gene
4615  MYD88; MYD88, innate immune signal transduction adaptor
51135  IRAK4; interleukin 1 receptor associated kinase 4
3654  IRAK1; interleukin 1 receptor associated kinase 1
7189  TRAF6; TNF receptor associated factor 6
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Perturbant
K23129  C; HBV capsid protein
Reference
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
  Authors
Bagheri V, Askari A, Arababadi MK, Kennedy D
  Title
Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?
  Journal
Hum Immunol 75:549-54 (2014)
DOI:10.1016/j.humimm.2014.02.018
Reference
  Authors
Zhang E, Lu M
  Title
Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection.
  Journal
Med Microbiol Immunol 204:11-20 (2015)
DOI:10.1007/s00430-014-0370-1
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