KEGG   NETWORK: N00551Help
Entry
N00551                      Network                                

Name
HBV HBs to TLR2/4-MAPK signaling pathway
Definition
hbvS -| JNK -> AP1
  Expanded
K23128 -| (5599,5601,5602) -> (2353,3725)
Class
nt06263 Hepatocellular carcinoma
nt06121 TLR signaling (viruses and bacteria)
nt06162 Hepatitis B virus (HBV)
Type
Pathogen
Pathway
hsa05161  Hepatitis B
Disease
H00048  Hepatocellular carcinoma
Gene
5599  MAPK8; mitogen-activated protein kinase 8
5601  MAPK9; mitogen-activated protein kinase 9
5602  MAPK10; mitogen-activated protein kinase 10
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit
Perturbant
K23128  S; HBV large envelope protein
Reference
  Authors
Bagheri V, Askari A, Arababadi MK, Kennedy D
  Title
Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?
  Journal
Hum Immunol 75:549-54 (2014)
DOI:10.1016/j.humimm.2014.02.018
Reference
  Authors
Wang S, Chen Z, Hu C, Qian F, Cheng Y, Wu M, Shi B, Chen J, Hu Y, Yuan Z
  Title
Hepatitis B virus surface antigen selectively inhibits TLR2 ligand-induced IL-12 production in monocytes/macrophages by interfering with JNK activation.
  Journal
J Immunol 190:5142-51 (2013)
DOI:10.4049/jimmunol.1201625
Reference
  Authors
Zhang E, Lu M
  Title
Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection.
  Journal
Med Microbiol Immunol 204:11-20 (2015)
DOI:10.1007/s00430-014-0370-1
Reference
  Authors
Nosratabadi R, Alavian SM, Zare-Bidaki M, Shahrokhi VM, Arababadi MK
  Title
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection.
  Journal
Mol Immunol 90:64-73 (2017)
DOI:10.1016/j.molimm.2017.07.002
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