KEGG   NETWORK: N00557Help
Entry
N00557                      Network                                

Name
HBV HBe to TLR2/4-NFKB signaling pathway
Definition
hbvC -| TIRAP -> (IRAK4+IRAK1) -> (TRAF6+TAK1+TAB2) -> IKK -> NFKBIA -> NFKB
  Expanded
K23129 -| 114609 -> (51135+3654) -> (7189+6885+23118) -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06263 Hepatocellular carcinoma
nt06121 TLR signaling (viruses and bacteria)
nt06162 Hepatitis B virus (HBV)
Type
Pathogen
Pathway
hsa05161  Hepatitis B
Disease
H00048  Hepatocellular carcinoma
Gene
114609  TIRAP; TIR domain containing adaptor protein
51135  IRAK4; interleukin 1 receptor associated kinase 4
3654  IRAK1; interleukin 1 receptor associated kinase 1
7189  TRAF6; TNF receptor associated factor 6
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Perturbant
K23129  C; HBV capsid protein
Reference
  Authors
Revill P, Yuan Z
  Title
New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.
  Journal
Antivir Ther 18:1-15 (2013)
DOI:10.3851/IMP2542
Reference
  Authors
Walsh R, Locarnini S
  Title
Hepatitis B precore protein: pathogenic potential and therapeutic promise.
  Journal
Yonsei Med J 53:875-85 (2012)
DOI:10.3349/ymj.2012.53.5.875
Reference
  Authors
Lang T, Lo C, Skinner N, Locarnini S, Visvanathan K, Mansell A
  Title
The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway.
  Journal
J Hepatol 55:762-9 (2011)
DOI:10.1016/j.jhep.2010.12.042
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