KEGG   NETWORK: N00558Help
Entry
N00558                      Network                                

Name
HBV pol to IFN signaling pathway
Definition
hbvP -| (STAT1+STAT2) => MYD88
  Expanded
K21037 -| (6772+6773) => 4615
Class
nt06263 Hepatocellular carcinoma
nt06122 IFN signaling (viruses)
nt06162 Hepatitis B virus (HBV)
Type
Pathogen
Pathway
hsa05161  Hepatitis B
Disease
H00048  Hepatocellular carcinoma
Gene
6772  STAT1; signal transducer and activator of transcription 1
6773  STAT2; signal transducer and activator of transcription 2
4615  MYD88; MYD88, innate immune signal transduction adaptor
Perturbant
K21037  P; Hepadnavirus DNA polymerase / reverse transcriptase / RNase H
Reference
  Authors
Dandri M, Locarnini S
  Title
New insight in the pathobiology of hepatitis B virus infection.
  Journal
Gut 61 Suppl 1:i6-17 (2012)
DOI:10.1136/gutjnl-2012-302056
Reference
  Authors
Wu M, Xu Y, Lin S, Zhang X, Xiang L, Yuan Z
  Title
Hepatitis B virus polymerase inhibits the interferon-inducible MyD88 promoter by blocking nuclear translocation of Stat1.
  Journal
J Gen Virol 88:3260-9 (2007)
DOI:10.1099/vir.0.82959-0
Reference
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
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