KEGG   NETWORK: N00559
Entry
N00559                      Network                                

Name
LIGHT-HVEM-NFKB signaling pathway
Definition
TNFSF14 -> TNFRSF14 -> TRAF2/5 -> IKK -> NFKBIA -> NFKB
  Expanded
8740 -> 8764 -> (7186,7188) -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06123 TNF signaling (viruses and bacteria)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Reference
Pathway
hsa04064  NF-kappa B signaling pathway
Gene
8740  TNFSF14; TNF superfamily member 14
8764  TNFRSF14; TNF receptor superfamily member 14
7186  TRAF2; TNF receptor associated factor 2
7188  TRAF5; TNF receptor associated factor 5
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Reference
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
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