KEGG   NETWORK: N00563
Entry
N00563                      Network                                

Name
TLR3-NFKB signaling pathway
Definition
TLR3 -> TICAM1 -> TRAF6 -> TAK1 -> IKK -> NFKBIA -> NFKB
  Expanded
7098 -> 148022 -> 7189 -> 6885 -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06121 TLR signaling (viruses and bacteria)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Reference
Pathway
hsa04620  Toll-like receptor signaling pathway
Gene
7098  TLR3; toll like receptor 3
148022  TICAM1; toll like receptor adaptor molecule 1
7189  TRAF6; TNF receptor associated factor 6
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Reference
  Authors
Kawai T, Akira S.
  Title
TLR signaling.
  Journal
Semin Immunol 19:24-32 (2007)
DOI:10.1016/j.smim.2006.12.004
Reference
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and innate immunity.
  Journal
J Mol Med 84:712-25 (2006)
DOI:10.1007/s00109-006-0084-y
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