KEGG   NETWORK: N00565Help
Entry
N00565                      Network                                

Name
HSV US11 to RIG-I-like receptor signaling pathway
Definition
hsvUS11 -| (DDX58,IFIH1) -> MAVS -> TRAF3 -> (TBK1+IKBKE) -> (IRF7,IRF3) => (IFNA,IFNB1)
  Expanded
K19438 -| (23586,64135) -> 57506 -> 7187 -> (29110+9641) -> (3665,3661) => ((3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452),3456)
Class
nt06133 RIG-I signaling (viruses)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
23586  DDX58; DExD/H-box helicase 58
64135  IFIH1; interferon induced with helicase C domain 1
57506  MAVS; mitochondrial antiviral signaling protein
7187  TRAF3; TNF receptor associated factor 3
29110  TBK1; TANK binding kinase 1
9641  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon
3665  IRF7; interferon regulatory factor 7
3661  IRF3; interferon regulatory factor 3
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
3456  IFNB1; interferon beta 1
Perturbant
K19438  US11; RNA-binding protein
Reference
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
  Authors
Xing J, Wang S, Lin R, Mossman KL, Zheng C
  Title
Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5.
  Journal
J Virol 86:3528-40 (2012)
DOI:10.1128/JVI.06713-11
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