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Entry
N00569                      Network                                

Name
HSV UL41 to cGAS-STING signaling pathway
Definition
hsvUL41 -| CGAS -> cGAMP -> TMEM173 -> TBK1 -> IRF3 => (IFNA,IFNB)
  Expanded
K19447 -| 115004 -> C20640 -> 340061 -> 29110 -> 3661 => ((3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452),3456)
Class
nt06134 CGAS-STING signaling (viruses and bacteria)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
115004  CGAS; cyclic GMP-AMP synthase
340061  TMEM173; transmembrane protein 173
29110  TBK1; TANK binding kinase 1
3661  IRF3; interferon regulatory factor 3
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
3456  IFNB1; interferon beta 1
Perturbant
K19447  UL41; virion host shutoff protein
Metabolite
C20640  Cyclic GMP-AMP
Reference
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
  Authors
Su C, Zheng C
  Title
Herpes Simplex Virus 1 Abrogates the cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway via Its Virion Host Shutoff Protein, UL41.
  Journal
J Virol 91:e02414-16 (2017)
DOI:10.1128/JVI.02414-16
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