KEGG   NETWORK: N00571Help
Entry
N00571                      Network                                

Name
PKR-eIF2alpha signaling pathway
Definition
EIF2AK2 -> EIF2S1 -| EIF2B
  Expanded
5610 -> 1965 -| (1967,8892,8891,8890,8893)
Class
nt06138 PKR-eIF2alpha signaling (viruses)
nt06169 Measles virus (MV)
nt06170 Influenza A virus (IAV)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Reference
Gene
5610  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2
1965  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha
1967  EIF2B1; eukaryotic translation initiation factor 2B subunit alpha
8892  EIF2B2; eukaryotic translation initiation factor 2B subunit beta
8891  EIF2B3; eukaryotic translation initiation factor 2B subunit gamma
8890  EIF2B4; eukaryotic translation initiation factor 2B subunit delta
8893  EIF2B5; eukaryotic translation initiation factor 2B subunit epsilon
Reference
  Authors
Taylor SS, Haste NM, Ghosh G
  Title
PKR and eIF2alpha: integration of kinase dimerization, activation, and substrate docking.
  Journal
Cell 122:823-5 (2005)
DOI:10.1016/j.cell.2005.09.007
Reference
  Authors
Wek RC, Jiang HY, Anthony TG
  Title
Coping with stress: eIF2 kinases and translational control.
  Journal
Biochem Soc Trans 34:7-11 (2006)
DOI:10.1042/BST20060007
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