KEGG   NETWORK: N00573Help
Entry
N00573                      Network                                

Name
HSV US11 to PKR-eIF2alpha signaling pathway
Definition
hsvUS11 -| EIF2AK2 -> EIF2S1 -| EIF2B
  Expanded
K19438 -| 5610 -> 1965 -| (1967,8892,8891,8890,8893)
Class
nt06138 PKR-eIF2alpha signaling (viruses)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
5610  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2
1965  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha
1967  EIF2B1; eukaryotic translation initiation factor 2B subunit alpha
8892  EIF2B2; eukaryotic translation initiation factor 2B subunit beta
8891  EIF2B3; eukaryotic translation initiation factor 2B subunit gamma
8890  EIF2B4; eukaryotic translation initiation factor 2B subunit delta
8893  EIF2B5; eukaryotic translation initiation factor 2B subunit epsilon
Perturbant
K19438  US11; RNA-binding protein
Reference
  Authors
Poppers J, Mulvey M, Khoo D, Mohr I
  Title
Inhibition of PKR activation by the proline-rich RNA binding domain of the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 74:11215-21 (2000)
Reference
  Authors
Leib DA
  Title
Counteraction of interferon-induced antiviral responses by herpes simplex viruses.
  Journal
Curr Top Microbiol Immunol 269:171-85 (2002)
DOI:10.1007/978-3-642-59421-2_11
Reference
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
  Authors
Walsh D, Mohr I
  Title
Viral subversion of the host protein synthesis machinery.
  Journal
Nat Rev Microbiol 9:860-75 (2011)
DOI:10.1038/nrmicro2655
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