KEGG   NETWORK: N00576Help
Entry
N00576                      Network                                

Name
HSV UL41/UL13 to IFN signaling pathway
Definition
(hsvUL41,hsvUL13) -> SOCS3 -| JAK1 -> (STAT1+STAT2+IRF9) => (ZAP1,EIF2AK,OAS)
  Expanded
(K19447,K19440) -> 9021 -| 3716 -> (6772+6773+10379) => (148266,27102,5610,9451,440275,4938,4939,4940)
Class
nt06122 IFN signaling (virus)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Virus
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
9021  SOCS3; suppressor of cytokine signaling 3
3716  JAK1; Janus kinase 1
6772  STAT1; signal transducer and activator of transcription 1
6773  STAT2; signal transducer and activator of transcription 2
10379  IRF9; interferon regulatory factor 9
148266  ZNF569; zinc finger protein 569
27102  EIF2AK1; eukaryotic translation initiation factor 2 alpha kinase 1
5610  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2
9451  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3
440275  EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4
4938  OAS1; 2'-5'-oligoadenylate synthetase 1
4939  OAS2; 2'-5'-oligoadenylate synthetase 2
4940  OAS3; 2'-5'-oligoadenylate synthetase 3
Perturbant
K19447  UL41; virion host shutoff protein
K19440  UL13; serine/threonine-protein kinase UL13
Reference
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
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