KEGG   NETWORK: N00577Help
Entry
N00577                      Network                                

Name
HSV UL41 to IFN signaling pathway
Definition
hsvUL41 -| JAK1 -> (STAT1+STAT2+IRF9) => (ZAP1,EIF2AK,OAS)
  Expanded
K19447 -| 3716 -> (6772+6773+10379) => (148266,27102,5610,9451,440275,4938,4939,4940)
Class
nt06122 IFN signaling (viruses)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
3716  JAK1; Janus kinase 1
6772  STAT1; signal transducer and activator of transcription 1
6773  STAT2; signal transducer and activator of transcription 2
10379  IRF9; interferon regulatory factor 9
148266  ZNF569; zinc finger protein 569
27102  EIF2AK1; eukaryotic translation initiation factor 2 alpha kinase 1
5610  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2
9451  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3
440275  EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4
4938  OAS1; 2'-5'-oligoadenylate synthetase 1
4939  OAS2; 2'-5'-oligoadenylate synthetase 2
4940  OAS3; 2'-5'-oligoadenylate synthetase 3
Perturbant
K19447  UL41; virion host shutoff protein
Reference
  Authors
Chee AV, Roizman B
  Title
Herpes simplex virus 1 gene products occlude the interferon signaling pathway at multiple sites.
  Journal
J Virol 78:4185-96 (2004)
DOI:10.1128/JVI.78.8.4185-4196.2004
Reference
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
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