KEGG   NETWORK: N00579
Entry
N00579                      Network                                

Name
HSV ICP6 to extrinsic apoptotic pathway
Definition
ICP6 -| CASP8
  Expanded
K19448 -| 841
Class
nt06131 Apoptosis (viruses and bacteria)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
841  CASP8; caspase 8
Perturbant
K19448 (ICP6)  UL39; Simplexvirus ribonucleoside-diphosphate reductase large subunit
Reference
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Reference
  Authors
Dufour F, Sasseville AM, Chabaud S, Massie B, Siegel RM, Langelier Y
  Title
The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNFalpha- and FasL-induced apoptosis by interacting with caspase-8.
  Journal
Apoptosis 16:256-71 (2011)
DOI:10.1007/s10495-010-0560-2
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