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Entry
N00581                      Network                                

Name
HSV ICP47 to antigen processing and presentation by MHC class I molecules
Definition
hsvICP47 -| TAP1/2 -- TAPBP -- (PDIA3+CALR) -> (MHCI+B2M)
  Expanded
K19446 -| (6890,6891) -- 6892 -- (2923+811) -> ((3105,3106,3107,3133,3134,3135)+567)
Class
nt06129 MHC presentation (viruses)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
6890  TAP1; transporter 1, ATP binding cassette subfamily B member
6891  TAP2; transporter 2, ATP binding cassette subfamily B member
6892  TAPBP; TAP binding protein
2923  PDIA3; protein disulfide isomerase family A member 3
811  CALR; calreticulin
3105  HLA-A; major histocompatibility complex, class I, A
3106  HLA-B; major histocompatibility complex, class I, B
3107  HLA-C; major histocompatibility complex, class I, C
3133  HLA-E; major histocompatibility complex, class I, E
3134  HLA-F; major histocompatibility complex, class I, F
3135  HLA-G; major histocompatibility complex, class I, G
567  B2M; beta-2-microglobulin
Perturbant
K19446  US12; ICP47 protein
Reference
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
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