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Entry
N00582                      Network                                

Name
IGF-IGF1R-PI3K signaling pathway
Definition
IGF1 -> IGF1R -> PI3K -> PIP3 -> AKT -| (TSC1+TSC2) -| RHEB -> MTOR -| EIF4EBP1
  Expanded
3479 -> 3480 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> (7248+7249) -| 6009 -> 2475 -| 1978
Class
nt06114 PI3K signaling (viruses)
nt06168 Herpes simplex virus 1 (HSV-1)
nt06167 Human cytomegalovirus (HCMV)
nt06166 Human papillomavirus (HPV)
Type
Reference
Pathway
hsa04151  PI3K-Akt signaling pathway
hsa04150  mTOR signaling pathway
Gene
3479  IGF1; insulin like growth factor 1
3480  IGF1R; insulin like growth factor 1 receptor
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
7248  TSC1; TSC complex subunit 1
7249  TSC2; TSC complex subunit 2
6009  RHEB; Ras homolog, mTORC1 binding
2475  MTOR; mechanistic target of rapamycin kinase
1978  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
  Authors
Meng D, Frank AR, Jewell JL
  Title
mTOR signaling in stem and progenitor cells.
  Journal
Development 145:dev152595 (2018)
DOI:10.1242/dev.152595
Reference
  Authors
Lamming DW
  Title
Diminished mTOR signaling: a common mode of action for endocrine longevity factors.
  Journal
Springerplus 3:735 (2014)
DOI:10.1186/2193-1801-3-735
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