KEGG   NETWORK: N00583Help
Entry
N00583                      Network                                

Name
HSV VP11/12 to PI3K signaling pathway
Definition
hsvVP11/12 -> PI3K -> PIP3 -> AKT -| (TSC1+TSC2) -| RHEB -> MTOR -| EIF4EBP1
  Expanded
K23212 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| (7248+7249) -| 6009 -> 2475 -| 1978
Class
nt06114 PI3K signaling (viruses)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
7248  TSC1; TSC complex subunit 1
7249  TSC2; TSC complex subunit 2
6009  RHEB; Ras homolog, mTORC1 binding
2475  MTOR; mechanistic target of rapamycin kinase
1978  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
Perturbant
K23212  UL46; HSV tegument protein VP11/12
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Wagner MJ, Smiley JR
  Title
Herpes simplex virus requires VP11/12 to activate Src family kinase-phosphoinositide 3-kinase-Akt signaling.
  Journal
J Virol 85:2803-12 (2011)
DOI:10.1128/JVI.01877-10
Reference
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
LinkDB All DBs

DBGET integrated database retrieval system