KEGG   NETWORK: N00585Help
Entry
N00585                      Network                                

Name
HSV US3 to intrinsic apoptotic pathway
Definition
hsvUS3 -| BAD -| (BCL2,BCL2L1) -| (BAX,BAK1) -> CYCS -- APAF1 -> CASP9 -> (CASP3,CASP7)
  Expanded
K19439 -| 572 -| (596,598) -| (581,578) -> 54205 -- 317 -> 842 -> (836,840)
Class
nt06131 Apoptosis (viruses and bacteria)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
572  BAD; BCL2 associated agonist of cell death
10018  BCL2L11; BCL2 like 11
596  BCL2; BCL2, apoptosis regulator
598  BCL2L1; BCL2 like 1
581  BAX; BCL2 associated X, apoptosis regulator
578  BAK1; BCL2 antagonist/killer 1
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
840  CASP7; caspase 7
Perturbant
K19439  US3; serine/threonine-protein kinase US3
Reference
  Authors
Ogg PD, McDonell PJ, Ryckman BJ, Knudson CM, Roller RJ
  Title
The HSV-1 Us3 protein kinase is sufficient to block apoptosis induced by overexpression of a variety of Bcl-2 family members.
  Journal
Virology 319:212-24 (2004)
DOI:10.1016/j.virol.2003.10.019
Reference
  Authors
Cartier A, Komai T, Masucci MG
  Title
The Us3 protein kinase of herpes simplex virus 1 blocks apoptosis and induces phosporylation of the Bcl-2 family member Bad.
  Journal
Exp Cell Res 291:242-50 (2003)
Reference
  Authors
Diehl N, Schaal H
  Title
Make yourself at home: viral hijacking of the PI3K/Akt signaling pathway.
  Journal
Viruses 5:3192-212 (2013)
DOI:10.3390/v5123192
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