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Entry
N00657                      Network                                

Name
ALG8 deficiency in N-glycan precursor biosynthesis
Definition
G00007+Glc-P-Dol -- ALG6 >> ALG8*
  Expanded
(G00007+C01246) -- 29929 >> 79053v1
Class
nt06015 N-Glycan biosynthesis
Type
Variant
Pathway
hsa00510  N-Glycan biosynthesis
Disease
H00118  Congenital disorders of glycosylation type I
Gene
29929  ALG6; ALG6, alpha-1,3-glucosyltransferase
79053  ALG8; ALG8, alpha-1,3-glucosyltransferase
Variant
79053v1  ALG8 deficiency
Metabolite
G00007   
C01246  Dolichyl beta-D-glucosyl phosphate
Reference
  Authors
Chantret I, Dancourt J, Dupre T, Delenda C, Bucher S, Vuillaumier-Barrot S, Ogier de Baulny H, Peletan C, Danos O, Seta N, Durand G, Oriol R, Codogno P, Moore SE
  Title
A deficiency in dolichyl-P-glucose:Glc1Man9GlcNAc2-PP-dolichyl alpha3-glucosyltransferase defines a new subtype of congenital disorders of glycosylation.
  Journal
J Biol Chem 278:9962-71 (2003)
DOI:10.1074/jbc.M211950200
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