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Entry
N00660                      Network                                

Name
ALG12 deficiency in N-glycan precursor biosynthesis
Definition
G00006+Man-P-Dol -- ALG3 >> ALG9 >> ALG12*
  Expanded
(G00006+G10617) -- 10195 >> 79796 >> 79087v1
Class
nt06015 N-Glycan biosynthesis
Type
Variant
Pathway
hsa00510  N-Glycan biosynthesis
Disease
H00118  Congenital disorders of glycosylation type I
Gene
10195  ALG3; ALG3, alpha-1,3- mannosyltransferase
79796  ALG9; ALG9, alpha-1,2-mannosyltransferase
79087  ALG12; ALG12, alpha-1,6-mannosyltransferase
Variant
79087v1  ALG12 deficiency
Metabolite
G00006   
G10617  Man-P-Dol
Reference
  Authors
Chantret I, Dupre T, Delenda C, Bucher S, Dancourt J, Barnier A, Charollais A, Heron D, Bader-Meunier B, Danos O, Seta N, Durand G, Oriol R, Codogno P, Moore SE
  Title
Congenital disorders of glycosylation type Ig is defined by a deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase.
  Journal
J Biol Chem 277:25815-22 (2002)
DOI:10.1074/jbc.M203285200
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