KEGG   NETWORK: N00688Help
Entry
N00688                      Network                                

Name
RIG-I-NFKB signaling pathway
Definition
DDX58 -> MAVS -> IKK -> NFKBIA -> NFKB => (IFNA,IFNB1)
  Expanded
23586 -> 57506 -> (1147+3551+8517) -> 4792 -> (4790+5970) => ((3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452),3456)
Class
nt06133 RIG-I signaling (viruses)
nt06169 Measles virus (MV)
nt06170 Influenza A virus (IAV)
Type
Reference
Pathway
hsa04622  RIG-I-like receptor signaling pathway
Gene
23586  DDX58; DExD/H-box helicase 58
57506  MAVS; mitochondrial antiviral signaling protein
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
3456  IFNB1; interferon beta 1
Reference
  Authors
Xie P
  Title
TRAF molecules in cell signaling and in human diseases.
  Journal
J Mol Signal 8:7 (2013)
DOI:10.1186/1750-2187-8-7
Reference
  Authors
Mu Y, Li M, Ding F, Ding Y, Ao J, Hu S, Chen X
  Title
De novo characterization of the spleen transcriptome of the large yellow croaker (Pseudosciaena crocea) and analysis of the immune relevant genes and pathways involved in the antiviral response.
  Journal
PLoS One 9:e97471 (2014)
DOI:10.1371/journal.pone.0097471
Reference
  Authors
Arnoult D, Carneiro L, Tattoli I, Girardin SE
  Title
The role of mitochondria in cellular defense against microbial infection.
  Journal
Semin Immunol 21:223-32 (2009)
DOI:10.1016/j.smim.2009.05.009
Reference
  Authors
Jensen S, Thomsen AR
  Title
Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion.
  Journal
J Virol 86:2900-10 (2012)
DOI:10.1128/JVI.05738-11
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