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Entry
N00692                      Network                                

Name
MV P to TLR2/4-NFKB signaling pathway
Definition
mvP -> TNFAIP3 -| (TRAF6+TAK1+TAB2) -> IKK -> NFKBIA -> NFKB => (IFNA,IFNB1)
  Expanded
K19377 -> 7128 -| (7189+6885+23118) -> (1147+3551+8517) -> 4792 -> (4790+5970) => ((3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452),3456)
Class
nt06121 TLR signaling (virus)
nt06169 Measles virus (MV)
Type
Virus
Pathway
hsa05162  Measles
Disease
H00394  Measles
Gene
7128  TNFAIP3; TNF alpha induced protein 3
7189  TRAF6; TNF receptor associated factor 6
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
3456  IFNB1; interferon beta 1
Perturbant
K19377  P; Morbillivirus phosphoprotein
Reference
  Authors
Gerlier D, Valentin H
  Title
Measles virus interaction with host cells and impact on innate immunity.
  Journal
Curr Top Microbiol Immunol 329:163-91 (2009)
DOI:10.1007/978-3-540-70523-9_8
Reference
  Authors
Yokota S, Okabayashi T, Yokosawa N, Fujii N
  Title
Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.
  Journal
FASEB J 22:74-83 (2008)
DOI:10.1096/fj.07-8976com
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