KEGG   NETWORK: N00693Help
Entry
N00693                      Network                                

Name
MV V/P to IFN signaling pathway
Definition
(mvV,mvP) -| JAK1 -> (STAT1+STAT2+IRF9) => (EIF2AK2,OAS,ADAR,MX1)
  Expanded
(K22281,K19377) -| 3716 -> (6772+6773+10379) => (5610,4938,4939,4940,103,4599)
Class
nt06122 IFN signaling (virus)
nt06169 Measles virus (MV)
Type
Virus
Pathway
hsa05162  Measles
Disease
H00394  Measles
Gene
3716  JAK1; Janus kinase 1
6772  STAT1; signal transducer and activator of transcription 1
6773  STAT2; signal transducer and activator of transcription 2
10379  IRF9; interferon regulatory factor 9
5610  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2
4938  OAS1; 2'-5'-oligoadenylate synthetase 1
4939  OAS2; 2'-5'-oligoadenylate synthetase 2
4940  OAS3; 2'-5'-oligoadenylate synthetase 3
103  ADAR; adenosine deaminase, RNA specific
4599  MX1; MX dynamin like GTPase 1
Perturbant
K22281  V; measles non-structural protein V
K19377  P; Morbillivirus phosphoprotein
Reference
  Authors
Jiang Y, Qin Y, Chen M
  Title
Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.
  Journal
Viruses 8:E308 (2016)
DOI:10.3390/v8110308
Reference
  Authors
Caignard G, Bourai M, Jacob Y, Tangy F, Vidalain PO
  Title
Inhibition of IFN-alpha/beta signaling by two discrete peptides within measles virus V protein that specifically bind STAT1 and STAT2.
  Journal
Virology 383:112-20 (2009)
DOI:10.1016/j.virol.2008.10.014
Reference
  Authors
Delpeut S, Noyce RS, Siu RW, Richardson CD
  Title
Host factors and measles virus replication.
  Journal
Curr Opin Virol 2:773-83 (2012)
DOI:10.1016/j.coviro.2012.10.008
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