KEGG   NETWORK: N00725Help
Entry
N00725                      Network                                

Name
IAV NS1 to PKR-eIF2alpha signaling pathway
Definition
iavNS1 -| EIF2AK2 -> EIF2S1
  Expanded
K19396 -| 5610 -> 1965
Class
nt06138 PKR-eIF2alpha signaling (viruses)
nt06170 Influenza A virus (IAV)
Type
Pathogen
Pathway
hsa05164  Influenza A
Disease
H00398  Influenza
Gene
5610  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2
1965  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha
Perturbant
K19396  NS1; non-structural protein 1
Reference
  Authors
Min JY, Li S, Sen GC, Krug RM
  Title
A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis.
  Journal
Virology 363:236-43 (2007)
DOI:10.1016/j.virol.2007.01.038
Reference
  Authors
Hale BG, Randall RE, Ortin J, Jackson D
  Title
The multifunctional NS1 protein of influenza A viruses.
  Journal
J Gen Virol 89:2359-76 (2008)
DOI:10.1099/vir.0.2008/004606-0
Reference
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
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