KEGG   NETWORK: N00726Help
Entry
N00726                      Network                                

Name
IAV NP to PKR-eIF2alpha signaling pathway
Definition
iavNP -| DNAJB1 -| DNAJC3 -| EIF2AK2 -> EIF2S1
  Expanded
K19391 -| 3337 -| 5611 -| 5610 -> 1965
Class
nt06138 PKR-eIF2alpha signaling (viruses)
nt06170 Influenza A virus (IAV)
Type
Pathogen
Pathway
hsa05164  Influenza A
Disease
H00398  Influenza
Gene
3337  DNAJB1; DnaJ heat shock protein family (Hsp40) member B1
5611  DNAJC3; DnaJ heat shock protein family (Hsp40) member C3
5610  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2
1965  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha
Perturbant
K19391  NP; nucleoprotein
Reference
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
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