KEGG   NETWORK: N00727Help
Entry
N00727                      Network                                

Name
IAV NS1 to RIG-I-like receptor signaling pathway
Definition
iavNS1 -| TRIM25 -> DDX58 -> MAVS -> TRAF3 -> (TBK1+IKBKE) -> IRF3 => IFNB1
  Expanded
K19396 -| 7706 -> 23586 -> 57506 -> 7187 -> (29110+9641) -> 3661 => 3456
Class
nt06133 RIG-I signaling (viruses)
nt06170 Influenza A virus (IAV)
Type
Pathogen
Pathway
hsa05164  Influenza A
Disease
H00398  Influenza
Gene
7706  TRIM25; tripartite motif containing 25
23586  DDX58; DExD/H-box helicase 58
57506  MAVS; mitochondrial antiviral signaling protein
7187  TRAF3; TNF receptor associated factor 3
29110  TBK1; TANK binding kinase 1
9641  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon
3661  IRF3; interferon regulatory factor 3
3456  IFNB1; interferon beta 1
Perturbant
K19396  NS1; non-structural protein 1
Reference
  Authors
Gack MU, Albrecht RA, Urano T, Inn KS, Huang IC, Carnero E, Farzan M, Inoue S, Jung JU, Garcia-Sastre A
  Title
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.
  Journal
Cell Host Microbe 5:439-49 (2009)
DOI:10.1016/j.chom.2009.04.006
Reference
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
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