KEGG   NETWORK: N00728
Entry
N00728                      Network                                

Name
IAV NS1 to RIG-I-like receptor signaling pathway
Definition
NS1 -| DDX58 -> MAVS -> TRAF3 -> (TBK1+IKBKE) -> IRF3 => IFNB1
  Expanded
K19396 -| 23586 -> 57506 -> 7187 -> (29110+9641) -> 3661 => 3456
Class
nt06133 RIG-I signaling (viruses)
nt06170 Influenza A virus (IAV)
Type
Pathogen
Pathway
hsa05164  Influenza A
Disease
H00398  Influenza
Gene
23586  DDX58; DExD/H-box helicase 58
57506  MAVS; mitochondrial antiviral signaling protein
7187  TRAF3; TNF receptor associated factor 3
29110  TBK1; TANK binding kinase 1
9641  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon
3661  IRF3; interferon regulatory factor 3
3456  IFNB1; interferon beta 1
Perturbant
K19396 (NS1)  NS1; Influenza A virus non-structural protein 1
Reference
  Authors
Pichlmair A, Schulz O, Tan CP, Naslund TI, Liljestrom P, Weber F, Reis e Sousa C
  Title
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates.
  Journal
Science 314:997-1001 (2006)
DOI:10.1126/science.1132998
Reference
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
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