KEGG   NETWORK: N00730Help
Entry
N00730                      Network                                

Name
IAV NS1 to RIG-I-like receptor signaling pathway
Definition
iavNS1 -| NFKB => (IFNA,IFNB1)
  Expanded
K19396 -| (4790+5970) => ((3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452),3456)
Class
nt06133 RIG-I signaling (viruses)
nt06170 Influenza A virus (IAV)
Type
Pathogen
Pathway
hsa05164  Influenza A
Disease
H00398  Influenza
Gene
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
3456  IFNB1; interferon beta 1
Perturbant
K19396  NS1; non-structural protein 1
Reference
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
  Authors
Wang X, Li M, Zheng H, Muster T, Palese P, Beg AA, Garcia-Sastre A
  Title
Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon.
  Journal
J Virol 74:11566-73 (2000)
DOI:10.1128/JVI.74.24.11566-11573.2000
Reference
  Authors
Ruckle A, Haasbach E, Julkunen I, Planz O, Ehrhardt C, Ludwig S
  Title
The NS1 protein of influenza A virus blocks RIG-I-mediated activation of the noncanonical NF-kappaB pathway and p52/RelB-dependent gene expression in lung epithelial cells.
  Journal
J Virol 86:10211-7 (2012)
DOI:10.1128/JVI.00323-12
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