KEGG   NETWORK: N00732Help
Entry
N00732                      Network                                

Name
IAV PB1-F2/PB2 to RIG-I-like receptor signaling pathway
Definition
(iavPB1F2,iavPB2) -| MAVS -> TRAF3 -> (TBK1+IKBKE) -> IRF3 => IFNB1
  Expanded
(K19397,K19388) -| 57506 -> 7187 -> (29110+9641) -> 3661 => 3456
Class
nt06170 Influenza A virus (IAV)
Type
Pathogen
Pathway
hsa05164  Influenza A
Disease
H00398  Influenza
Gene
57506  MAVS; mitochondrial antiviral signaling protein
7187  TRAF3; TNF receptor associated factor 3
29110  TBK1; TANK binding kinase 1
9641  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon
3661  IRF3; interferon regulatory factor 3
3456  IFNB1; interferon beta 1
Perturbant
K19397  PB1F2; protein PB1-F2
K19388  PB2; polymerase basic protein 2
Reference
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
  Authors
Varga ZT, Ramos I, Hai R, Schmolke M, Garcia-Sastre A, Fernandez-Sesma A, Palese P
  Title
The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor protein.
  Journal
PLoS Pathog 7:e1002067 (2011)
DOI:10.1371/journal.ppat.1002067
Reference
  Authors
Dudek SE, Wixler L, Nordhoff C, Nordmann A, Anhlan D, Wixler V, Ludwig S
  Title
The influenza virus PB1-F2 protein has interferon antagonistic activity.
  Journal
Biol Chem 392:1135-44 (2011)
DOI:10.1515/BC.2011.174
Reference
  Authors
Graef KM, Vreede FT, Lau YF, McCall AW, Carr SM, Subbarao K, Fodor E
  Title
The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.
  Journal
J Virol 84:8433-45 (2010)
DOI:10.1128/JVI.00879-10
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