KEGG   NETWORK: N00736
Entry
N00736                      Network                                

Name
IAV NS1 to PI3K signaling pathway
Definition
NS1 -> PI3K -> PIP3 -> AKT
  Expanded
K19396 -> (5290,5291,5293) -> C05981 -> (207,208,10000)
Class
nt06114 PI3K signaling (viruses)
nt06170 Influenza A virus (IAV)
Type
Pathogen
Pathway
hsa05164  Influenza A
Disease
H00398  Influenza
Gene
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Perturbant
K19396 (NS1)  NS1; Influenza A virus non-structural protein 1
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
  Authors
Hale BG, Jackson D, Chen YH, Lamb RA, Randall RE
  Title
Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling.
  Journal
Proc Natl Acad Sci U S A 103:14194-9 (2006)
DOI:10.1073/pnas.0606109103
Reference
  Authors
Hale BG, Randall RE, Ortin J, Jackson D
  Title
The multifunctional NS1 protein of influenza A viruses.
  Journal
J Gen Virol 89:2359-76 (2008)
DOI:10.1099/vir.0.2008/004606-0
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