KEGG   NETWORK: N00738Help
Entry
N00738                      Network                                

Name
IAV NS1 to IFN signaling pathway
Definition
iavNS1 -> SOCS3 -| (STAT1+STAT2+IRF9) => (OAS,MX1)
  Expanded
K19396 -> 9021 -| (6772+6773+10379) => (4938,4939,4940,4599)
Class
nt06122 IFN signaling (viruses)
nt06170 Influenza A virus (IAV)
Type
Pathogen
Pathway
hsa05164  Influenza A
Disease
H00398  Influenza
Gene
9021  SOCS3; suppressor of cytokine signaling 3
6772  STAT1; signal transducer and activator of transcription 1
6773  STAT2; signal transducer and activator of transcription 2
10379  IRF9; interferon regulatory factor 9
4938  OAS1; 2'-5'-oligoadenylate synthetase 1
4939  OAS2; 2'-5'-oligoadenylate synthetase 2
4940  OAS3; 2'-5'-oligoadenylate synthetase 3
4599  MX1; MX dynamin like GTPase 1
Perturbant
K19396  NS1; non-structural protein 1
Reference
  Authors
Zheng J, Yang P, Tang Y, Pan Z, Zhao D
  Title
Respiratory Syncytial Virus Nonstructural Proteins Upregulate SOCS1 and SOCS3 in the Different Manner from Endogenous IFN Signaling.
  Journal
J Immunol Res 2015:738547 (2015)
DOI:10.1155/2015/738547
Reference
  Authors
Nan Y, Wu C, Zhang YJ
  Title
Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism.
  Journal
Front Immunol 8:1758 (2017)
DOI:10.3389/fimmu.2017.01758
Reference
  Authors
Jia D, Rahbar R, Chan RW, Lee SM, Chan MC, Wang BX, Baker DP, Sun B, Peiris JS, Nicholls JM, Fish EN
  Title
Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling.
  Journal
PLoS One 5:e13927 (2010)
DOI:10.1371/journal.pone.0013927
Reference
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
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