KEGG   NETWORK: N00743Help
Entry
N00743                      Network                                

Name
IAV NS1 to NLRP3 inflammasome signaling pathway
Definition
iavNS1 -| (NLRP3+PYCARD) -> CASP1 -> (IL1B,IL18,IL33)
  Expanded
K19396 -| (114548+29108) -> 834 -> (3553,3606,90865)
Class
nt06139 NLR signaling (viruses and bacteria)
nt06170 Influenza A virus (IAV)
Type
Pathogen
Pathway
hsa05164  Influenza A
Disease
H00398  Influenza
Gene
114548  NLRP3; NLR family pyrin domain containing 3
29108  PYCARD; PYD and CARD domain containing
834  CASP1; caspase 1
3553  IL1B; interleukin 1 beta
3606  IL18; interleukin 18
90865  IL33; interleukin 33
Perturbant
K19396  NS1; non-structural protein 1
Reference
  Authors
Chung WC, Kang HR, Yoon H, Kang SJ, Ting JP, Song MJ
  Title
Influenza A Virus NS1 Protein Inhibits the NLRP3 Inflammasome.
  Journal
PLoS One 10:e0126456 (2015)
DOI:10.1371/journal.pone.0126456
Reference
  Authors
Moriyama M, Chen IY, Kawaguchi A, Koshiba T, Nagata K, Takeyama H, Hasegawa H, Ichinohe T
  Title
The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1beta Secretion.
  Journal
J Virol 90:4105-4114 (2016)
DOI:10.1128/JVI.00120-16
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