KEGG   NETWORK: N00745Help
Entry
N00745                      Network                                

Name
IAV PB1-F2 to intrinsic apoptotic pathway
Definition
iavPB1F2 -- (VDAC1+SLC25A6) -> CYCS -- APAF1 -> CASP9 -> CASP3
  Expanded
K19397 -- (7416+293) -> 54205 -- 317 -> 842 -> 836
Class
nt06131 Apoptosis (viruses and bacteria)
nt06170 Influenza A virus (IAV)
Type
Pathogen
Pathway
hsa05164  Influenza A
Disease
H00398  Influenza
Gene
7416  VDAC1; voltage dependent anion channel 1
293  SLC25A6; solute carrier family 25 member 6
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
Perturbant
K19397  PB1F2; protein PB1-F2
Reference
  Authors
Danishuddin M, Khan SN, Khan AU
  Title
Molecular interactions between mitochondrial membrane proteins and the C-terminal domain of PB1-F2: an in silico approach.
  Journal
J Mol Model 16:535-41 (2010)
DOI:10.1007/s00894-009-0555-5
Reference
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
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