KEGG   NETWORK: N00791
Entry
N00791                      Network                                

Name
Deiodination of MIT and DIT
Definition
(MIT,DIT) -- IYD -> Iodide
  Expanded
(C02515,C01060) -- 389434 -> C00708
Class
nt06322 TRH-TSH-TH signaling
Type
Reference
Pathway
hsa04918  Thyroid hormone synthesis
Gene
389434  IYD; iodotyrosine deiodinase
Metabolite
C02515  3-Iodo-L-tyrosine
C01060  3,5-Diiodo-L-tyrosine
C00708  Iodide
Reference
  Authors
Leung A, Pearce EN, Braverman LE
  Title
Role of iodine in thyroid physiology.
  Journal
Expert Rev Endocrinol Metab 5:593-602 (2010)
DOI:10.1586/eem.10.40
Reference
  Authors
Shimizu R
  Title
Iodotyrosine deiodinase, a novel target of environmental halogenated chemicals for disruption of the thyroid hormone system in mammals.
  Journal
Biol Pharm Bull 37:1430-4 (2014)
DOI:10.1248/bpb.b14-00240
Reference
  Authors
Gnidehou S, Lacroix L, Sezan A, Ohayon R, Noel-Hudson MS, Morand S, Francon J, Courtin F, Virion A, Dupuy C
  Title
Cloning and characterization of a novel isoform of iodotyrosine dehalogenase 1 (DEHAL1) DEHAL1C from human thyroid: comparisons with DEHAL1 and DEHAL1B.
  Journal
Thyroid 16:715-24 (2006)
DOI:10.1089/thy.2006.16.715
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