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Entry
N00793                      Network                                

Name
TSH-DUOX2-TG signaling pathway
Definition
TSHB -> TSHR -> GNAQ -> PLCB -> (Ca2+,DAG) -> PKC -> DUOX2 -> H2O2 -> TG
  Expanded
7252 -> 7253 -> 2776 -> (23236,5330,5331,5332) -> (C00076,C00165) -> (5578,5579,5582) -> 50506 -> C00027 -> 7038
Class
nt06322 TRH-TSH-TH signaling
Type
Reference
Pathway
hsa04918  Thyroid hormone synthesis
Gene
7252  TSHB; thyroid stimulating hormone subunit beta
7253  TSHR; thyroid stimulating hormone receptor
2776  GNAQ; G protein subunit alpha q
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
5578  PRKCA; protein kinase C alpha
5579  PRKCB; protein kinase C beta
5582  PRKCG; protein kinase C gamma
50506  DUOX2; dual oxidase 2
7038  TG; thyroglobulin
Metabolite
C00076  Calcium cation
C00165  Diacylglycerol
C00027  Hydrogen peroxide
Reference
  Authors
Ohye H, Sugawara M
  Title
Dual oxidase, hydrogen peroxide and thyroid diseases.
  Journal
Exp Biol Med (Maywood) 235:424-33 (2010)
DOI:10.1258/ebm.2009.009241
Reference
  Authors
Massart C, Hoste C, Virion A, Ruf J, Dumont JE, Van Sande J
  Title
Cell biology of H2O2 generation in the thyroid: investigation of the control of dual oxidases (DUOX) activity in intact ex vivo thyroid tissue and cell lines.
  Journal
Mol Cell Endocrinol 343:32-44 (2011)
DOI:10.1016/j.mce.2011.05.047
Reference
  Authors
Gillam MP, Kopp P
  Title
Genetic defects in thyroid hormone synthesis.
  Journal
Curr Opin Pediatr 13:364-72 (2001)
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