KEGG   NETWORK: N00795
Entry
N00795                      Network                                

Name
DUOX2-generated H2O2 production
Definition
DUOXA2 -> DUOX2 -> H2O2
  Expanded
405753 -> 50506 -> C00027
Class
nt06322 TRH-TSH-TH signaling
Type
Reference
Pathway
hsa04918  Thyroid hormone synthesis
Gene
405753  DUOXA2; dual oxidase maturation factor 2
50506  DUOX2; dual oxidase 2
Metabolite
C00027  Hydrogen peroxide
Reference
  Authors
Grasberger H, Refetoff S
  Title
Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent.
  Journal
J Biol Chem 281:18269-72 (2006)
DOI:10.1074/jbc.C600095200
Reference
  Authors
MacFie TS, Poulsom R, Parker A, Warnes G, Boitsova T, Nijhuis A, Suraweera N, Poehlmann A, Szary J, Feakins R, Jeffery R, Harper RW, Jubb AM, Lindsay JO, Silver A
  Title
DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid.
  Journal
Inflamm Bowel Dis 20:514-24 (2014)
DOI:10.1097/01.MIB.0000442012.45038.0e
Reference
  Authors
Szanto I, Pusztaszeri M, Mavromati M
  Title
H2O2 Metabolism in Normal Thyroid Cells and in Thyroid Tumorigenesis: Focus on NADPH Oxidases.
  Journal
Antioxidants (Basel) 8:E126 (2019)
DOI:10.3390/antiox8050126
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