KEGG   NETWORK: N00885
Entry
N00885                      Network                                

Name
LHCGR-GNAS-PKA signaling pathway
Definition
(LHB+CGA) -> LHCGR -> GNAS -> ADCY -> cAMP -> PKA
  Expanded
(3972+1081) -> 3973 -> 2778 -> (107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568)
Class
nt06323 KISS1-GnRH-LH/FSH-E2 signaling
Type
Reference
Pathway
hsa04024  cAMP signaling pathway
Gene
3972  LHB; luteinizing hormone beta polypeptide
1081  CGA; glycoprotein hormones, alpha polypeptide
3973  LHCGR; luteinizing hormone/choriogonadotropin receptor
2778  GNAS; GNAS complex locus
107  ADCY1; adenylate cyclase 1
108  ADCY2; adenylate cyclase 2
109  ADCY3; adenylate cyclase 3
196883  ADCY4; adenylate cyclase 4
111  ADCY5; adenylate cyclase 5
112  ADCY6; adenylate cyclase 6
113  ADCY7; adenylate cyclase 7
114  ADCY8; adenylate cyclase 8
115  ADCY9; adenylate cyclase 9
5566  PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567  PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568  PRKACG; protein kinase cAMP-activated catalytic subunit gamma
Metabolite
C00575  3',5'-Cyclic AMP
Reference
  Authors
Choi J, Smitz J
  Title
Luteinizing hormone and human chorionic gonadotropin: origins of difference.
  Journal
Mol Cell Endocrinol 383:203-13 (2014)
DOI:10.1016/j.mce.2013.12.009
Reference
  Authors
Bjelic MM, Stojkov NJ, Baburski AZ, Sokanovic SJ, Mihajlovic AI, Janjic MM, Kostic TS, Andric SA
  Title
Molecular adaptations of testosterone-producing Leydig cells during systemic in vivo blockade of the androgen receptor.
  Journal
Mol Cell Endocrinol 396:10-25 (2014)
DOI:10.1016/j.mce.2014.08.007
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