KEGG   NETWORK: N00913Help
Entry
N00913                      Network                                

Name
Mutation-inactivated IGF1 to RAS-ERK signaling pathway
Definition
IGF* // IGF1R -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
3479v1 // 3480 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06324 GHRH-GH-IGF signaling
Type
Variant
Pathway
hsa04010  MAPK signaling pathway
Disease
H02040  Insulin-like growth factor I deficiency
Gene
3479  IGF1; insulin like growth factor 1
3480  IGF1R; insulin like growth factor 1 receptor
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Variant
3479v1  IGF1 mutation
Reference
  Authors
Troncoso R, Ibarra C, Vicencio JM, Jaimovich E, Lavandero S
  Title
New insights into IGF-1 signaling in the heart.
  Journal
Trends Endocrinol Metab 25:128-37 (2014)
DOI:10.1016/j.tem.2013.12.002
Reference
  Authors
Savage MO, Hwa V, David A, Rosenfeld RG, Metherell LA
  Title
Genetic Defects in the Growth Hormone-IGF-I Axis Causing Growth Hormone Insensitivity and Impaired Linear Growth.
  Journal
Front Endocrinol (Lausanne) 2:95 (2011)
DOI:10.3389/fendo.2011.00095
Reference
  Authors
Perrini S, Laviola L, Carreira MC, Cignarelli A, Natalicchio A, Giorgino F
  Title
The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis.
  Journal
J Endocrinol 205:201-10 (2010)
DOI:10.1677/JOE-09-0431
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