KEGG   NETWORK: N00915
Entry
N00915                      Network                                

Name
AVP-V2R-PKA signaling pathway
Definition
AVP -> AVPR2 -> GNAS -> ADCY3/6/9 -> cAMP -> PKA -> AQP2
  Expanded
551 -> 554 -> 2778 -> (109,112,115) -> C00575 -> (5566+5567+5568) -> 359
Class
nt06326 AVP signaling
Type
Reference
Pathway
hsa04962  Vasopressin-regulated water reabsorption
Gene
551  AVP; arginine vasopressin
554  AVPR2; arginine vasopressin receptor 2
2778  GNAS; GNAS complex locus
109  ADCY3; adenylate cyclase 3
112  ADCY6; adenylate cyclase 6
115  ADCY9; adenylate cyclase 9
5566  PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567  PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568  PRKACG; protein kinase cAMP-activated catalytic subunit gamma
359  AQP2; aquaporin 2
Metabolite
C00575  3',5'-Cyclic AMP
Reference
  Authors
Boone M, Deen PM
  Title
Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.
  Journal
Pflugers Arch 456:1005-24 (2008)
DOI:10.1007/s00424-008-0498-1
Reference
  Authors
Takata K, Matsuzaki T, Tajika Y, Ablimit A, Hasegawa T
  Title
Localization and trafficking of aquaporin 2 in the kidney.
  Journal
Histochem Cell Biol 130:197-209 (2008)
DOI:10.1007/s00418-008-0457-0
Reference
  Authors
Nielsen S, Kwon TH, Christensen BM, Promeneur D, Frokiaer J, Marples D
  Title
Physiology and pathophysiology of renal aquaporins.
  Journal
J Am Soc Nephrol 10:647-63 (1999)
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